Wetenschappelijk onderzoek

Lutke Schipholt IJ, van Onna MM, van Dieën JH, Pisters MF, Das EJ, Quax R, Scholten-Peeters GGM. Why neck pain persists: rethinking neck pain recovery through a complex systems approach. Musculoskelet Sci Pract. 2026 Oct;85:103621. doi: 10.1016/j.msksp.2026.103621. Epub 2026 Jul 17. PMID: 42481272.

Marinelli FE, Lutke Schipholt IJ, Klein Heerenbrink S, Coppieters MW, van Dongen JM, Ostelo RWJG, Kielstra SC, Vleggeert-Lankamp CLA, Arts MP, Ter Meulen B, Bosboom HJLW, van Nassau F, Coenen P, Rooker S, Sleijser-Koehorst MLS; MOVE-IT Research Group; Scholten-Peeters GGM. (Cost-)Effectiveness of personalised multimodal physiotherapy compared to surgery in patients with painful cervical radiculopathy. Protocol for a randomised non-inferiority trial (The MOVE-IT study). Contemp Clin Trials Commun. 2026 Mar 9;51:101626. doi: 10.1016/j.conctc.2026.101626. PMID: 41858839; PMCID: PMC12996693.

Amstel RNV, Lutke Schipholt IJ, Weide G, Pool-Goudzwaard AL, Jaspers RT. Neuroimmune interactions in fascia and myofiber regeneration: a narrative review. Musculoskelet Sci Pract. 2026 Apr;82:103507. doi: 10.1016/j.msksp.2026.103507. Epub 2026 Feb 5. PMID: 41663286.

Lutke Schipholt IJ, Coppieters MW, Koop MA, Boellaard R, van de Giessen E, Vleggeert-Lankamp C, Depauw PR, van Berckel BNM, Lammerstma AA, Yaqub M, Scholten-Peeters GGM. Neuroinflammation in the nerve roots and dorsal root ganglion decreases following 6 weeks of neural tissue management: PET/CT imaging findings in a patient with painful cervical radiculopathy. Musculoskelet Sci Pract. 2026 Apr;82:103502. doi: 10.1016/j.msksp.2026.103502. Epub 2026 Jan 31. PMID: 41620319.

Lutke Schipholt IJ, Coppieters MW, Scholten-Peeters GGM, Hutchinson MR, Klyne DM. Neuroimmune interactions in musculoskeletal conditions. An introduction for clinicians. Musculoskelet Sci Pract. 2026 Feb;81:103469. doi: 10.1016/j.msksp.2025.103469. Epub 2025 Dec 11. PMID: 41422597.

Lutke Schipholt IJ, Scholten-Peeters GGM, Koop MA, Coppieters MW, Boellaard R, van de Giessen E, Ter Meulen BC, Coenen M, Vleggeert-Lankamp C, Depaauw PR, van Berckel BNM, Lammerstma AA, Yaqub M. Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [¹¹C]DPA713 PET/CT. Front Nucl Med. 2025 Aug 21;5:1569991. doi: 10.3389/fnume.2025.1569991. PMID: 40918986; PMCID: PMC12408627.

Lutke Schipholt IJ, Koop MA, Coppieters MW, van de Giessen EM, Lammerstma AA, Ter Meulen BC, Vleggeert-Lankamp C, van Berckel BNM, Bot J, van Helvoirt H, Depauw PR, Boellaard R, Yaqub M, Scholten-Peeters G. Neuroinflammation at the Neuroforamina and Spinal Cord in Patients with Painful Cervical Radiculopathy and Pain-Free Participants: An [¹¹C]DPA713 PET/CT Proof-of-Concept Study. J Clin Med. 2025 Apr 2;14(7):2420. doi: 10.3390/jcm14072420. PMID: 40217878; PMCID: PMC11989976.

Lutke Schipholt IJ, Scholten-Peeters GGM, Logghe S, Koop M, Donders S, Stenneberg MS, Coppieters MW. The CROM-VAS Test: A novel and reliable clinical test to assess immediate pain relief following treatment for movement-evoked neck pain. Musculoskelet Sci Pract. 2024 Nov;74:103191. doi: 10.1016/j.msksp.2024.103191. Epub 2024 Sep 21. PMID: 39321586.

Klein Heerenbrink S, Coenen P, Coppieters MW, van Dongen JM, Vleggeert-Lankamp CLA, Rooker S, Ter Meulen BC, Bosboom JLW, Bouma GJ, Lutke Schipholt IJ, Sleijser-Koehorst MLS, de Vries R, Ostelo RWJG, Scholten-Peeters GGM. (Cost-)effectiveness of personalised multimodal physiotherapy compared to surgery in patients with cervical radiculopathy: A systematic review. J Eval Clin Pract. 2024 Oct;30(7):1227-1238. doi: 10.1111/jep.14036. Epub 2024 Jun 2. PMID: 38825757.

Lutke Schipholt IJ, Coppieters MW, Diepens M, Hoekstra T, Ostelo RWJG, Barbe MF, Meijer OG, Bontkes HJ, Scholten-Peeters GGM. Systemic Inflammation, Sleep, and Psychological Factors Determine Recovery Trajectories for People With Neck Pain: An Exploratory Study. J Pain. 2024 Aug;25(8):104496. doi: 10.1016/j.jpain.2024.02.010. Epub 2024 Feb 9. PMID: 38342190; PMCID: PMC12006975.

Koop MA, Sleijser-Koehorst MLS, Hooijmans CR, Tdlohreg PQ, Lutke Schipholt IJ, Scholten-Peeters GGM, Coppieters MW. The potential protective effects of pre-injury exercise on neuroimmune responses following experimentally-induced traumatic neuropathy: a systematic review with meta-analysis. Front Immunol. 2023 Sep 11;14:1215566. doi: 10.3389/fimmu.2023.1215566. PMID: 37767095; PMCID: PMC10520553.

Lutke Schipholt IJ, Coppieters MW, Reijm M, Bontkes HJ, Scholten-Peeters GGM. Immediate systemic neuroimmune responses following spinal mobilisation and manipulation in people with non-specific neck pain: a randomised placebo-controlled trial. Sci Rep. 2023 Aug 7;13(1):12804. doi: 10.1038/s41598-023-39839-3. PMID: 37550491; PMCID: PMC10406885.

Sleijser-Koehorst MLS, Koop MA, Coppieters MW, Lutke Schipholt IJ, Radisic N, Hooijmans CR, Scholten-Peeters GGM. The effects of aerobic exercise on neuroimmune responses in animals with traumatic peripheral nerve injury: a systematic review with meta-analyses. J Neuroinflammation. 2023 May 3;20(1):104. doi: 10.1186/s12974-023-02777-y. PMID: 37138291; PMCID: PMC10155410.

Lutke Schipholt IJ, Scholten-Peeters GGM, Koop MA, Bonnet P, Bontkes HJ, Coppieters MW. Systemic neuroimmune responses in people with non-specific neck pain and cervical radiculopathy, and associations with clinical, psychological, and lifestyle factors. Front Mol Neurosci. 2022 Oct 13;15:1003821. doi: 10.3389/fnmol.2022.1003821. PMID: 36311017; PMCID: PMC9608367.

Lutke Schipholt IJ, Scholten-Peeters G, Bontkes H, Coppieters MW. Neuroimmune responses following joint mobilisation and manipulation in people with persistent neck pain: a protocol for a randomised placebo-controlled trial. BMJ Open. 2022 Mar 8;12(3):e055748. doi: 10.1136/bmjopen-2021-055748. PMID: 35260459; PMCID: PMC8905979.

Koop MA, Lutke Schipholt IJ, Scholten-Peeters GGM, Coppieters MW. Identifying the Most Important Confounders When Assessing the Association Between Low-Grade Systemic Inflammation and Musculoskeletal Pain: A Modified Delphi Study. Pain Med. 2021 Nov 26;22(11):2661-2669. doi: 10.1093/pm/pnab243. PMID: 34343332; PMCID: PMC8633774.

Lutke Schipholt IJ, Coppieters MW, Meijer OG, Tompra N, de Vries RBM, Scholten-Peeters GGM. Effects of joint and nerve mobilisation on neuroimmune responses in animals and humans with neuromusculoskeletal conditions: a systematic review and meta-analysis. Pain Rep. 2021 Jun 3;6(2):e927. doi: 10.1097/PR9.0000000000000927. PMID: 34104836; PMCID: PMC8177878.

Lutke Schipholt IJ, Scholten-Peeters GGM, Bontkes HJ, Coppieters MW. Authors' Reply: Confounding and mediation to reveal the true association between systemic inflammation and musculoskeletal pain. Spine J. 2019 Nov;19(11):1901. doi: 10.1016/j.spinee.2019.06.013. PMID: 31668334.

Lutke Schipholt IJ, Scholten-Peeters GGM, Bontkes HJ, Coppieters MW. Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature. Spine J. 2018 Nov;18(11):2162-2163. doi: 10.1016/j.spinee.2018.07.019. Epub 2018 Jul 26. PMID: 30055262.